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KMID : 0882420160900020154
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Korean Journal of Medicine
2016 Volume.90 No. 2 p.154 ~ p.158
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Three Types of Cancer in a Patient with Neurofibromatosis Type I: Gastrointestinal Stromal Tumor, Breast and Ampulla of Vater Cancer
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김효은:Kim Hyo-Eun
조재용:Cho Jae-Yong/황창혁:Hwang Chang-Hyeok/양성연:Yang Seo-Yeon/천유진:Chun You-Jin/최성민:Choi Sung-Min/최성은:Choi Sung-Eun
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Abstract
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Neurofibromatosis type 1 (NF-1) is an autosomal dominant disorder with a prevalence of approximately 1 in 3,500 live births. NF-1 predisposes to various benign and malignant neoplasms. Neurological malignancies are most frequent, but the risks of non-nervous system tumors, such as of the esophagus, stomach, colon, liver, biliary tract, pancreas, lung, melanoma, thyroid gland, female breast and ovaries, are also increased. Malignant tumors are the most common cause of death in patients with NF-1. Cases with double primary tumors have been reported, but cases involving three or more primary cancers are rarely reported. Therefore, we present the case of a NF-1 patient diagnosed with gastrointestinal stromal tumor, breast cancer and ampulla of Vater cancer.
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KEYWORD
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Neurofibromatosis, Gastrointestinal stromal tumors, Breast neoplasm, Ampulla of vater
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